Heart Valves

Biological (bovine or porcine) or mechanical heart valves were already commercially available when a cardiac surgery program was started at the MHH around 1970. Both were continuously improved with regard to complications and long-term functionality, but there were no valves for smaller children. Here we have produced our own cell-free valve from our experimental laboratory, the superiority of which over all other procedures has now been reflected in guidelines. Whenever possible, we try to preserve the patient's own valve. We have performed the largest number of aortic valve procedures worldwide with the so-called David reconstruction.

Aortic valve-sparing root replacement with Tirone E. David‘sreimplantation technique: single-centre 25-year experience - EN

Regarding long-term outcome, David's AVSRR seems to provide excellent clinical results and sustainable function of the aortic valve in the majority of patients almost 3 decades after its introduction.

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Medical ethics : The blessed heart valves for Moldova - EN

Is this the culmination of a campaign? Heart surgeon Axel Haverich has been excluded from the Future Prize because of patent issues. His team was unfairly accused of questionable treatment trials “in poor foreign countries”.

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Surgical treatment of active infective endocarditis with paravalvular involvement - EN

The use of an antibiotic fibrin compound appears to be a useful prophylactic tool to prevent postoperative residual endocarditis.

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Tissue engineering of pulmonary heart valves on allogenic acellular matrix conduits: in vivo restoration of valve tissue - EN

Tissue engineering using in vitro-cultivated autologous vascular wall cells is a new approach to biological heart valve replacement. In the present study, we analyzed a new concept to process allogenic acellular matrix scaffolds.

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Toward acellular xenogeneic heart valve prostheses: Histological and biomechanical characterization of decellularized and enzymatically deglycosylated porcine pulmonary heart valve matrices - EN

The use of decellularized xenogeneic heart valves might offer a solution to overcome the issue of human valve shortage. The aim of this study was to revise decellularization protocols in combination with enzymatic deglycosylation, in order to reduce immunogenicity.

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Prof. dr. dr. h.c. Axel Haverich