Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis EN

Atherosclerosis Aachen

In January of this year, an important paper on the pathophysiology of atherosclerosis was published from Aachen. Published in Nature Cardiovascular research, the investigations confirm all the characteristics of our work on the development of atherosclerosis. In particular, the role of the adventitia and the outside-in concept. In addition, the special role of the vasa vasorum is described, from which the inflammatory process appears to be initiated. The sub-intimal region of the arterial wall is also described as the ‘focal point’ of the first cellular changes, all of this based on microsections of human plaques (‘indicating an intricate cellular interplay within the adventitia and the subendothelial space in human atherosclerosis’)

doi: 10.1038/s44161-024-00582

Prof. dr. dr. h.c. Axel Haverich