Disease Initiation and Prevention

Research into the causes of the development of arteriosclerosis has been going on for over 150 years without a conclusive result. Based on our clinical and surgical observations, we have postulated that the typically culprit inner layer of the arteries (T. intima) is not responsible for the development and progression, but that the process begins in the outer layer (T. adventitia) and penetrates the vessel wall via small blood vessels (vv. vasorum).
Recently, we were able to show in animal experiments that a comparable mechanism is possible for pulmonary hypertension.
The loss of function of these small vessels is often due to inflammation, so with this knowledge new, more effective forms of prevention (exercise, diet) can be used.